Monit (Isosorbide mononitrate) Coupons, Discounts & Cost
Isosorbide mononitrate is a vasodilator drug that is used mainly in the treatment of angina. One way to save money on the Monit retail cost regardless of income and insurance status is to use Monit coupons or discount cards from RXCoupons. Use this Isosorbide mononitrate coupon at this online pharmacy and receive up to 75% off the sale price.
What should you know about Monit?
Isosorbide mononitrate is a vasodilator drug that is used mainly in the treatment of angina. It acts by dilating blood vessels and reducing blood pressure.
Isosorbide mononitrate is a peripheral vasodilator with an effect on venous vessels. It stimulates the formation of nitric oxide and reduces myocardial oxygen demand. The drug increases exercise tolerance in patients with coronary heart disease and angina.
The effect occurs within 30-45 minutes after ingestion and lasts up to 8-10 hours.
Monit works well among those people who have angina (prophylaxis), heart failure, hypertension, pulmonary heart disease (combination therapy), spasm of peripheral arteries (arterial occlusive disease).
What should you know about Monit contraindications?
The main contraindications for Monit (isosorbide mononitrate) are the following:
- Hypersensitivity;
- Hemorrhagic stroke;
- Head trauma;
- Acute myocardial infarction (risk of reduction in blood pressure and tachycardia, which may enhance ischemia);
- Glaucoma (risk of increased intraocular pressure);
- Severe anemia;
- Hyperthyroidism;
- Low systolic blood pressure (may cause paradoxical bradycardia and angina);
- Severe renal failure, hepatic failure (risk of methemoglobinemia);
- Pregnancy, lactation;
- Children's age.
What should you know about Monit side effects?
Cardiovascular system: headache, dizziness, facial flushing, tachycardia, low blood pressure. In rare cases - angina attacks (paradoxical reaction), and collapse.
Digestive system: nausea, vomiting, dry mouth.
Nervous system: drowsiness, blurred vision (especially at the beginning of treatment). In rare cases - cerebral ischemia.
Allergic reactions: skin rash.
Other reactions: exfoliative dermatitis.
Overdose symptoms: fainting, headache, dizziness, palpitations, visual disturbances, hyperthermia, seizures, skin flushing, sweating, nausea, vomiting, diarrhea, methemoglobinemia (cyanosis, anoxia - in cases of chronic overdose), hyperpnea, dyspnea, bradycardia, increased intracranial pressure, paralysis, coma.
Monit dosage
Monit tablets, capsules: 1 hour before or 2 hours after eating. Take without chewing, with a glass of water. The initial dose is 10-20 mg 2 times a day or 40-50 mg 1 time per day (for extended release capsules). The dose can be increased up to 20-40 mg two times a day, or, if necessary, up to 60-80 mg per day. The maximum daily dose is 80 mg.
Monit interaction with other drugs
Monit increases the concentration of dihydroergotamine.
Barbiturates accelerate metabolism and reduce the concentration of isosorbide mononitrate.
Other antihypertensive drugs, vasodilators, antipsychotic drugs (neuroleptics), tricyclic antidepressants, procainamide, ethanol, quinidine, beta-blockers, dihydroergotamine and sildenafil may increase the hypotensive effect of Monit.
Amiodarone, propranolol, verapamil, nifedipine may increase the antianginal effect of the drug.
Beta-agonists and alpha-blockers (dihydroergotamine, etc.) may reduce the severity of antianginal effects (tachycardia and excessive reduction of blood pressure).
Atropine may cause high eye pressure.
Adsorbents reduce the absorption of isosorbide mononitrate in the digestive tract.
What should you know about Monit special instructions?
Patients should monitor blood pressure and heart rate during treatment.
High doses can cause tolerance; in this case, it is recommended to cancel the therapy for 24-48 hours or make a break for 3-5 days after 3-6 weeks of regular reception (use other antianginal drugs).
Avoid drinking excessive amounts of alcohol during treatment.
Abrupt discontinuation should be avoided (the dose should be reduced gradually).
Store Monit in dry and dark place, at a temperature between 15° and 25° C. Keep out of the reach of children.